Clinical characteristics among asymptomatic PART subjects

 
   Lead Investigator:    Lilah Besser
   Institution      :    NACC
   E-Mail           :    lmbesser@uw.edu
   Proposal ID      :    639


   Publications:


1  Besser LM, Mock C, Teylan MA , Hassenstab J,  Kukull WA , Crary JF
   Differences in cognitive impairment in primary age-related tauopathy versus Alzheimer's disease
   Journal Article  J Neuro Expo Neurol,3:219-228,2017,PMC6380319

   PUBLISHED



2  Besser LM , Crary JF,  Mock C, Kukull WA
   Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy
   Journal Article  Neurology,89:1707-1715,2017,PMC5644462

   PUBLISHED





   Proposal Description:
   1. To compare the neuropathologic and demographic characteristics of people with tau only pathology (defined as Braak stage I or higher in the absence of any amyloid pathology) vs. people with the presence of amyloid at autopsy. 2. To discern whether the above comparison is affected by the definition of amyloid used: Thal phase >= 1 (defined the the NACC NP as any diffuse plaque) or CERAD >= 1 or either. 3. To identify factors associated with clinical manifestations (MCI or demnetia) of underlying tau pathology (i.e. compare the factors that might be contributing to whether someone with underlying tau pathology in the absence of amyloid has or does not have cognitive symptoms). 4. To determine whether asymptomatic persons with tau pathology (in the absence of amyloid) differ in their cognitive status compared to asymptomatic persons without tau pathology and to determine the trajectory of these potential changes over time.